Publications

1. Du F, Yu Q, Swerdlow RH, Waites CL. Glucocorticoid-driven mitochondrial damage stimulates Tau pathology. Brain. 2023 Apr 18;. doi: 10.1093/brain/awad127. [Epub ahead of print] PubMed PMID: 37070763.

2. Gomes PA, Bodo C, Nogueras-Ortiz C, Samiotaki M, Chen M, Soares-Cunha C, Silva JM, Coimbra B, Stamatakis G, Santos L, Panayotou G, Tzouanou F, Waites CL, Gatsogiannis C, Sousa N, Kapogiannis D, Costa-Silva B, Sotiropoulos I. A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology. Cell Commun Signal. 2023 Feb 13;21(1):35. doi: 10.1186/s12964-023-01045-z. PubMed PMID: 36782237; PubMed Central PMCID: PMC9926669.

3. Gomes P, Tzouanou F, Skolariki K, Vamvaka-Iakovou A, Noguera-Ortiz C, Tsirtsaki K, Waites CL, Vlamos P, Sousa N, Costa-Silva B, Kapogiannis D, Sotiropoulos I. Extracellular vesicles and Alzheimer's disease in the novel era of Precision Medicine: implications for disease progression, diagnosis and treatment. Exp Neurol. 2022 Dec;358:114183. doi: 10.1016/j.expneurol.2022.114183. Epub 2022 Aug 8. PMID: 35952764.

4. Birdsall V, Kirwan K, Zhu M, Imoto Y, Wilson SM, Watanabe S, Waites CL. Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradation. Life Sci Alliance. 2022 May 30;5(10):e202000745. doi: 10.26508/lsa.202000745. PMID: 35636965; PMCID: PMC9152131.

5. Zhuravleva V, Vaz-Silva J, Zhu M, Gomes P, Silva JM, Sousa N, Sotiropoulos I, Waites CL. Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production. Cell Death Dis. 2021 Dec 8;12(12):1137. doi: 10.1038/s41419-021-04433-w. PMID: 34876559; PMCID: PMC8651661.

6. Monteiro-Fernandes D, Silva JM, Soares-Cunha C, Dalla C, Kokras N, Arnaud F, Billiras R, Zhuravleva V, Waites C, Bretin S, Sousa N, Sotiropoulos I.Allosteric modulation of AMPA receptors counteracts Tau-related excitotoxic synaptic signaling and memory deficits in stress- and Aβ-evoked hippocampal pathology. Mol Psychiatry. 2021 Oct;26(10):5899-5911. doi: 10.1038/s41380-020-0794-5. Epub 2020 May 28. PubMed PMID: 32467647.

7. Waites C, Qu X, Bartolini F. The synaptic life of microtubules. Curr Opin Neurobiol. 2021 Aug;69:113-123. doi: 10.1016/j.conb.2021.03.004. Epub 2021 Apr 16. Review. PubMed PMID: 33873059; PubMed Central PMCID: PMC8387337.

8. Qu X, Kumar A, Blockus H, Waites C, Bartolini F. Activity-Dependent Nucleation of Dynamic Microtubules at Presynaptic Boutons Controls Neurotransmission. Curr Biol. 2019 Dec 16;29(24):4231-4240.e5. doi: 10.1016/j.cub.2019.10.049. Epub 2019 Dec 5. PubMed PMID: 31813605; PubMed Central PMCID: PMC6917861.

9. Birdsall V, Waites CL. Autophagy at the synapse. Neurosci Lett. 2019 Apr 1;697:24-28. doi: 10.1016/j.neulet.2018.05.033. Epub 2018 May 23. Review. PubMed PMID: 29802916; PubMed Central PMCID: PMC6251759.

10. Sheehan P, Waites CL. Coordination of synaptic vesicle trafficking and turnover by the Rab35 signaling network. Small GTPases. 2019 Jan;10(1):54-63. doi: 10.1080/21541248.2016.1270392. Epub 2017 Jan 27. Review. PubMed PMID: 28129039; PubMed Central PMCID: PMC6343537.

11. Sheehan P, Waites CL. Coordination of synaptic vesicle trafficking and turnover by the Rab35 signaling network. Small GTPases. 2019 Jan;10(1):54-63. doi: 10.1080/21541248.2016.1270392. Epub 2017 Jan 27. PMID: 28129039; PMCID: PMC6343537.

12. Birdsall V, Martinez JC, Randolph L, Hengst U, Waites CL.  Live Imaging of ESCRT Proteins in Microfluidically Isolated Hippocampal Axons.  Methods Mol Biol. 2019;1998:117-128. doi: 10.1007/978-1-4939-9492-2_9. PMID: 31250298; PMCID: PMC8882341.

13. Vaz-Silva J, Gomes P, Jin Q, Zhu M, Zhuravleva V, Quintremil S, Meira T, Silva J, Dioli C, Soares-Cunha C, Daskalakis NP, Sousa N, Sotiropoulos I, Waites CL. Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction. EMBO J. 2018 Oct 15;37(20):e99084. doi: 10.15252/embj.201899084. Epub 2018 Aug 30. PMID: 30166454; PMCID: PMC6187216.

14. Zhu M, Cortese GP, Waites CL. Parkinson's disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons. BMC Biol. 2018 Sep 10;16(1):100. doi: 10.1186/s12915-018-0567-7. PMID: 30200940; PMCID: PMC6130078.

15. Dunn M, Boltaev U, Beskow A, Pampou S, Realubit R, Meira T, Silva JV, Reeb R, Karan C, Jockusch S, Sulzer D, Chang YT, Sames D, Waites CL. Identification of Fluorescent Small Molecule Compounds for Synaptic Labeling by Image-Based, High-Content Screening. ACS Chem Neurosci. 2018 Apr 18;9(4):673-683. doi: 10.1021/acschemneuro.7b00263. Epub 2017 Dec 18. PubMed PMID: 29215865; PubMed Central PMCID: PMC8919986.

16. Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC. Bassoon Controls Presynaptic Autophagy through Atg5. Neuron. 2018 Feb 7;97(3):727. doi: 10.1016/j.neuron.2018.01.010. Erratum for: Neuron. 2017 Feb 22;93(4):897-913.e7. PMID: 29420936.

17. Goodman L, Baddeley D, Ambroziak W, Waites CL, Garner CC, Soeller C, Montgomery JM. N-terminal SAP97 isoforms differentially regulate synaptic structure and postsynaptic surface pools of AMPA receptors. Hippocampus. 2017 Jun;27(6):668-682. doi: 10.1002/hipo.22723. Epub 2017 Mar 20. PMID: 28244171.

18. Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC. Bassoon Controls Presynaptic Autophagy through Atg5. Neuron. 2017 Feb 22;93(4):897-913.e7. doi: 10.1016/j.neuron.2017.01.026. Erratum in: Neuron. 2018 Feb 7;97(3):727. PMID: 28231469.

19. Terry-Lorenzo RT, Torres VI, Wagh D, Galaz J, Swanson SK, Florens L, Washburn MP, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC. Trio, a Rho Family GEF, Interacts with the Presynaptic Active Zone Proteins Piccolo and Bassoon. PLoS One. 2016 Dec 1;11(12):e0167535. doi: 10.1371/journal.pone.0167535. PMID: 27907191; PMCID: PMC5132261.

20. Cortese GP, Zhu M, Williams D, Heath S, Waites CL. Parkin Deficiency Reduces Hippocampal Glutamatergic Neurotransmission by Impairing AMPA Receptor Endocytosis. J Neurosci. 2016 Nov 30;36(48):12243-12258. doi: 10.1523/JNEUROSCI.1473-16.2016. PMID: 27903732; PMCID: PMC5148221.

21. Waites CL. Activity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT Pathway. J Neurosci. 2016 Aug 17;36(33):8668-86. doi: 10.1523/JNEUROSCI.0725-16.2016. PMID: 27535913; PMCID: PMC4987437.

22. Ackermann F, Waites CL, Garner CC. Presynaptic active zones in invertebrates and vertebrates. EMBO Rep. 2015 Aug;16(8):923-38. doi: 10.15252/embr.201540434. Epub 2015 Jul 9. PMID: 26160654; PMCID: PMC4552486.

23. Wagh D, Terry-Lorenzo R, Waites CL, Leal-Ortiz SA, Maas C, Reimer RJ, Garner CC. Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1. PLoS One. 2015 Apr 21;10(4):e0120093. doi: 10.1371/journal.pone.0120093. PMID: 25897839; PMCID: PMC4405365.

24. Waites CL, Leal-Ortiz SA, Okerlund N, Dalke H, Fejtova A, Altrock WD, Gundelfinger ED, Garner CC. Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation. EMBO J. 2013 Apr 3;32(7):954-69. doi: 10.1038/emboj.2013.27. Epub 2013 Feb 12. PMID: 23403927; PMCID: PMC3616282.

25. Waites CL, Leal-Ortiz SA, Andlauer TF, Sigrist SJ, Garner CC. Piccolo regulates the dynamic assembly of presynaptic F-actin. J Neurosci. 2011 Oct 5;31(40):14250-63. doi: 10.1523/JNEUROSCI.1835-11.2011. PMID: 21976510; PMCID: PMC3210199.

26. Li D, Specht CG, Waites CL, Butler-Munro C, Leal-Ortiz S, Foote JW, Genoux D, Garner CC, Montgomery JM. SAP97 directs NMDA receptor spine targeting and synaptic plasticity. J Physiol. 2011 Sep 15;589(Pt 18):4491-510. doi: 10.1113/jphysiol.2011.215566. Epub 2011 Jul 18. PMID: 21768261; PMCID: PMC3208220.

27. Hua Z, Leal-Ortiz S, Foss SM, Waites CL, Garner CC, Voglmaier SM, Edwards RH. v-SNARE composition distinguishes synaptic vesicle pools. ​Neuron. 2011 Aug 11;71(3):474-87. doi: 10.1016/j.neuron.2011.06.010. PMID: 21835344; PMCID: PMC3155686.

28. Waites CL, Garner CC. Presynaptic function in health and disease. Trends Neurosci. 2011 Jun;34(6):326-37. doi: 10.1016/j.tins.2011.03.004. Epub 2011 May 17. PMID: 21596448.

29. Jeyifous O, Waites CL, Specht CG, Fujisawa S, Schubert M, Lin EI, Marshall J, Aoki C, de Silva T, Montgomery JM, Garner CC, Green WN. SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway. Nat Neurosci. 2009 Aug;12(8):1011-9. doi: 10.1038/nn.2362. Epub 2009 Jul 20. PMID: 19620977; PMCID: PMC2779056.

30. Waites CL, Specht CG, Härtel K, Leal-Ortiz S, Genoux D, Li D, Drisdel RC, Jeyifous O, Cheyne JE, Green WN, Montgomery JM, Garner CC. Synaptic SAP97 isoforms regulate AMPA receptor dynamics and access to presynaptic glutamate. J Neurosci. 2009 Apr 8;29(14):4332-45. doi: 10.1523/JNEUROSCI.4431-08.2009. PMID: 19357261; PMCID: PMC3230533.

31. Leal-Ortiz S, Waites CL, Terry-Lorenzo R, Zamorano P, Gundelfinger ED, Garner CC. Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis. J Cell Biol. 2008 Jun 2;181(5):831-46. doi: 10.1083/jcb.200711167. PMID: 18519737; PMCID: PMC2396795.

32. Garner CC, Waites CL, Ziv NE. Synapse development: still looking for the forest, still lost in the trees. Cell Tissue Res. 2006 Nov;326(2):249-62. doi: 10.1007/s00441-006-0278-1. Epub 2006 Aug 15. PMID: 16909256.

33. Regalado MP, Terry-Lorenzo RT, Waites CL, Garner CC, Malenka RC. Transsynaptic signaling by postsynaptic synapse-associated protein 97. J Neurosci. 2006 Feb 22;26(8):2343-57. doi: 10.1523/JNEUROSCI.5247-05.2006. PMID: 16495462; PMCID: PMC6674804.

34. Li H, Waites CL, Staal RG, Dobryy Y, Park J, Sulzer DL, Edwards RH. Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines. Neuron. 2005 Nov 23;48(4):619-33. doi: 10.1016/j.neuron.2005.09.033. PMID: 16301178.

35. Waites CL, Craig AM, Garner CC. Mechanisms of vertebrate synaptogenesis. Annu Rev Neurosci. 2005;28:251-74. doi: 10.1146/annurev.neuro.27.070203.144336. PMID: 16022596.

36. Waites CL, Mehta A, Tan PK, Thomas G, Edwards RH, Krantz DE. An acidic motif retains vesicular monoamine transporter 2 on large dense core vesicles. J Cell Biol. 2001 Mar 19;152(6):1159-68. doi: 10.1083/jcb.152.6.1159. PMID: 11257117; PMCID: PMC2199206.

37. Liu Y, Krantz DE, Waites C, Edwards RH. Membrane trafficking of neurotransmitter transporters in the regulation of synaptic transmission. Trends Cell Biol.1999 Sep;9(9):356-63. doi: 10.1016/s0962-8924(99)01605-0. Review. PubMed PMID: 10461189.

38. Tan PK, Waites C, Liu Y, Krantz DE, Edwards RH. A leucine-based motif mediates the endocytosis of vesicular monoamine and acetylcholine transporters.J Biol Chem. 1998 Jul 10;273(28):17351-60. doi: 10.1074/jbc.273.28.17351. PubMed PMID: 9651318.

39. Liu Y, Waites C, Krantz D, Tan P, Edwards RH. Molecular analysis of neurotransmitter transport into secretory vesicles. Cold Spring Harb Symp Quant Biol.1996;61:747-58. Review. PubMed PMID: 9246500.

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